A couple years ago, I posted about the ruins of the "City of the Monkey God" that was found in the jungles of Honduras.
It turns out that exploring the lost city is even more difficult than anticipated. Besides the remote, overgrown nature of the location, there are vipers and parasitic diseases which make visiting the area extremely dangerous. Many of the team members exploring the site were infected after being bitten by sand flies.
This has given rise to the idea that the city is "cursed" in some way. However, it is more attributable the fact that it is in a wild and hostile jungle environment. Having a legend around the city makes it more exciting and dramatic, but the fact is that rainforests are usually inhospitable due to predators and disease.
The only "curse" is that of human mortality, in the face of dangerous circumstances.